Friday, October 25, 2013

Cos., patients shop for better health care deals

Dr. Keith Smith, right, an anesthesiologist who started Surgery Center of Oklahoma, looks on as Dr. Don McGinnis, left, and physician's assistant Steve Popielec, right, perform a surgery at the center in Oklahoma City, Thursday, Oct. 10, 2013. Through a website called Medibid, some patients who pay out of pocket for their care are soliciting doctors, hospitals and medical centers, including this one, to bid to perform non-emergency procedures. (AP Photo/Sue Ogrocki)







Dr. Keith Smith, right, an anesthesiologist who started Surgery Center of Oklahoma, looks on as Dr. Don McGinnis, left, and physician's assistant Steve Popielec, right, perform a surgery at the center in Oklahoma City, Thursday, Oct. 10, 2013. Through a website called Medibid, some patients who pay out of pocket for their care are soliciting doctors, hospitals and medical centers, including this one, to bid to perform non-emergency procedures. (AP Photo/Sue Ogrocki)







Dr. Keith Smith, right, of Surgery Center of Oklahoma, prepares a patient for surgery at the center in Oklahoma City on Thursday, Oct. 10, 2013. Registered nurse Karen Barger is at left. Smith bids often on Medibid requests. He says his physician-owned center can offer better rates than some competitors because it doesn’t charge a high facility fee like many hospitals do. (AP Photo/Sue Ogrocki)







This Wednesday, Oct. 9, 2013 photo shows the entrance to Surgery Center of Oklahoma in Oklahoma City. The center posts their prices on their website and say they offer better deals than other providers because they don’t charge a huge facility fee, which is a big price driver for hospitals or other surgery centers. (AP Photo/Sue Ogrocki)







Paul Freeman drove 600 miles last year to save himself — and his employer — thousands of dollars on his surgery.

Freeman's insurer covered his travel costs and the entire bill because a medical center in Oklahoma City could remove the loose cartilage in his knee for about 70 percent less than a hospital closer to Freeman's Texhoma, Okla., home.

At first, the community bank CEO hesitated because he thought the lower price would mean lower quality. But he knew if he didn't make the roughly 10-hour roundtrip trek, he'd pay about $5,000 out-of-pocket.

"You immediately think, 'Oh they're going to take me into a butcher shop and it's going to be real scary,'" Freeman, 53, says, noting that instead he had "a wonderful experience."

People shop for deals on everything from cars to clothes to computers. Why not for health care too?

Insurers, employers and individuals are shopping around for health care as they try to tame rising health care costs. Companies are doing things like paying for workers to travel if they agree to have a surgery performed in another city where the cost is cheaper. They're also providing online tools to help people search for better deals in their home market.

And some patients are bargain hunting on their own. Through a website called MediBid, people who pay out of pocket are soliciting doctors, hospitals and medical centers to bid to perform knee surgeries and other non-emergency procedures.

Patients who shop for care represent a tiny slice of the roughly $2.7 trillion spent annually on health care in the U.S., said Devon Herrick, an economist who studies health care for the National Center for Policy Analysis. But he and other experts expect this trend to grow, especially as more companies offer insurance plans that require employees to pay thousands of dollars before most coverage starts. These so-called high-deductible plans also will be among the cheapest options available on the public exchanges set up as part of the health care overhaul to enable millions of uninsured people to shop for coverage.

Advocates say all the shopping will help control medical spending.

"We waste an enormous amount of money in this country by overpaying for health care," says John Goodman, an economist and CEO of the National Center for Policy Analysis. "The only way to get rid of waste is to have people compete in a real marketplace."

Searching for health care deals is a big change for many patients who're used to paying whatever their insurer didn't. Just figuring out an appropriate price for a procedure can be difficult for the average person.

Surgeries and other major procedures have different prices based on a variety of factors, including whether it's performed in a big city where care can cost more or in a hospital. And the portion that patients pay can vary widely. A lot depends on the type of insurance coverage and other factors like the leverage a provider has in negotiating rates.

For instance, a patient in Detroit with high-deductible health coverage provided by an employer could pay $920 or $2,791 out of pocket for a colonoscopy, according to research done by health care technology firm Castlight Health. Same patient. Same insurance coverage. Only difference: Where the procedure is performed.

"You can be a highly educated consumer now and still not understand what bill is going to hit you," says Dr. Giovanni Colella, CEO of Castlight, which designs an application that insurers or employers can give to patients to help them shop for health care based on price and quality.

It's also tough for patients to measure quality versus price. "You may find something (more expensive), but it doesn't mean it's better, safer, or more efficient," says Arthur Caplan, a medical ethicist at NYU Langone Medical Center.

Insurers and employers are encouraging workers to become more educated. They say quality is a priority when they ask patients if they want a better deal.

Wal-Mart Stores Inc., the largest private U.S. employer, provides health coverage for 1.1 million employees and their dependents. It runs a voluntary Centers of Excellence program that sends people to one of six hospital systems around the U.S. for certain heart, spine and transplant surgeries at no cost to the patient.

Wal-Mart spokesman Randy Hargrove says the program can save a patient between $5,000 and $10,000 in out-of-pocket costs, depending on their coverage. He says so far, dozens of patients have used the program that includes care providers at nationally-recognized places such as the Mayo Clinic.

The retailer also recently said it would start offering no-cost knee and hip replacement surgeries for employees who travel to one of four U.S. hospital systems. Wal-Mart is doing this through a national Employers Centers of Excellence Network that it joined with other big companies like the home improvement chain Lowe's.

Premera Blue Cross Blue Shield, Alaska's biggest health insurer, started a program in January that will pay expenses for some of its members to fly to Seattle for some procedures that come with huge price breaks. For instance, a knee surgery that costs $27,100 in Alaska can be performed for $13,000 in Seattle, according to the insurer.

A Premera spokesman says only a couple people have used the program so far, but the insurer expects use to pick up as it includes more members next year.

Some patients are deal hunting on their own. The website Medibid, which launched in 2010, connects patients who are paying out of pocket with doctors who bid to provide care. The website's founders say they've helped about 1,800 people find care.

Patients register with the site and pay either $25 per request or $4.95 a month for a year so they can post their medical needs on the site to solicit bids. Care providers, who register and pay fees of either $24.90 per month or about $250 annually, respond to patients with a bid.

Tess St. Clair, Medibid's chief operating officer, says the site helps people weigh their health care options: "The hardest thing for an American to do is ask the question how much will this cost and get an answer."

Dr. Keith Smith, with the Surgery Center of Oklahoma, bids often on Medibid requests. Smith says his physician-owned center can offer better rates than some competitors because it doesn't charge a high facility fee like many hospitals do. The center competes on price and cuts out insurers.

Smith says this approach forces it to offer good care: The center cannot hide in an insurer's network and continue to receive patients regardless of the job it does.

"If we started cutting corners and worrying about our pocketbook before doing the right thing, we're going to lose our business," he says.

Rick Matthews, a motivational speaker, saved money on his hernia surgery last year by putting it up for bid on Medibid and having the procedure at Surgery Center of Oklahoma. Matthews, 62, decided to use Medibid after he learned that the care would cost about $20,000 without insurance at a hospital close to his Milaca, Minn., home.

Matthews pays for health care through a Christian cost-sharing ministry in which members chip in to help cover medical bills. He didn't want to stick them with a big bill. A doctor on Medibid said the surgery would cost about $3,600, including removing a cyst on his knuckle.

Counting costs for the roughly 1,400-plus mile roundtrip drive, Matthews figures the cost was about $4,500 — more than 70 percent off the original estimate.

Associated PressSource: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2013-10-25-Shopping%20for%20Health%20Care/id-39b5bb32ea834282b3020a5aa1f20848
Category: Red Sox Schedule   Once Upon A Time In Wonderland   bo pelini   sunday night football   H&m  

Box Office Is About To Get Schooled By A Jackass 'Grandpa'


A-list stuffed 'The Counselor' could lose box-office battle to old-man Knoxville.


By Ryan J. Downey








Source:
http://www.mtv.com/news/articles/1716183/jackass-bad-grandpa-gravity-box-office-preview.jhtml

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WSOF Unveils Title Belt Ahead of WSOF 6


The World Series of Fighting has unveiled their championship belt ahead of their inaugural welterweight title fight between Steve Carl and Josh Burkman at WSOF 6. The belt will be awarded at the conclusion of Saturday’s main event in Miami. WSOF officials announced the new belt via press release.



Custom-designed by A.J. LaFons, the World Series of Fighting championship belt features more than 43 carats of genuine ruby, diamond, emerald, sapphire and red garnet and weighs in at a total of 10 pounds, 7 ounces.


“We wanted to make sure our championship belt was reflective of our commitment to excellence,” World Series of Fighting President Way Sefo said. “We’ve been working in the background for more than a year on the design of this belt, and we feel like we got it right. On Saturday night, I feel confident that either Josh Burkman or Steve Carl will be proud of the belt they receive as recognition of their accomplishment as our first-ever welterweight champion.”



WSOF 6 will take place on the campus of the University of Miami on October 26. The October 26 NBC Sports Network lineup will be headlined by a WSOF welterweight championship pairing between Josh Burkman and Steve Carl. The card will be co-headlined by the fast-rising Marlon Moraes taking on his fellow prospect in Carson Beebe.


Stay tuned to MMAFrenzy for the latest WSOF 6 and the latest World Series of Fighting News.




Source: http://mmafrenzy.com/95370/wsof-unveils-title-belt-ahead-of-wsof-6/
Category: homeland   new orleans saints   2013 Emmy Winners   Julius Thomas   us open tennis  

Nokia debuts its first Windows tablet, two 'phablets,' and three cheap phones


Nokia has added a tablet and two large-screen smartphones to its Lumia family, and is once again counting on its camera technology to attract buyers.


The Lumia 2520 tablet -- which runs Microsoft's much-criticized Windows RT operating system, has a 10-inch HD screen and is powered by Qualcomm's Snapdragon 800 processor. It has a 6.7-megapixel camera that can take pictures in low light conditions, unlike those on other tablets, according to Nokia. The screen is also bright enough to be read in sunlight, the company said.


Nokia has developed a keyboard with an integrated battery that can add up to five hours of extra life after the integrated 8000 mAh battery has given up. Unlike Microsoft's Surface 2 tablet, whch was released today, the Lumia 2520 has LTE as well as Wi-Fi.


Additionally, the Lumia 2520 includes Storyteller, a Nokia-developed app that combines images and videos as a story on a map, as well as Nokia Video Director, which offers the ability to edit videos shot on the tablet.


The Nokia Lumia 2520 will cost about $499 before taxes and subsidies, and will start shipping in the U.S., the U.K. and Finland before the end of the year. Additional countries to follow shortly after, Nokia said.


"Nokia is fully aware of the challenge it faces in tablets. The 2520 will be a difficult sell owing to the challenges of Windows RT, but Nokia is rightly playing to its strengths," said Geoff Blaber, director of devices and platforms at CCS Insight.


The Lumia 1320 and Lumia 1520 smartphones, revealed today as well, both run Windows Phone 8 and have 6-inch screens. The 1520 is the high-end model, with a full HD screen, LTE, and a quad-core Snapdragon 800 processor. The device has 32GB of storage, which can be expanded by another 64GB using a MicroSD card slot, something that has been missing from recent Nokia smartphones.


Nokia is leaning on its camera technology to differentiate its products from rivals. The Lumia 1520 has a 20-megapixel camera with optical image stabilization. Nokia has also developed a new app called Camera that lets users access settings more easily, the company said.


The Lumia 1520 will start shipping this quarter in Hong Kong, Singapore, the U.S., China, the U.K., France, Germany, and Finland. The price will be $749, before taxes and subsidies.


The Lumia 1320 will cost $339 before taxes and subsidies, but only has a dual-core processor and 720p screen resolution. It also has a simpler 5-megapixel camera, but users can still access the Internet using LTE. Nokia expects to start shipping it in the first quarter of 2014 in China and Vietnam, followed by other Asian markets, India, and Europe.


The lower price will make the smartphone a good fit for the Chinese market, said Pete Cunningham, a principal analyst at Canalys.


Both devices will run a new version of Windows Phone 8 called General Distribution Release 3, to which Nokia has added enhancements such as its Camera app. The software will also be offered to users of existing Lumia devices via an update called Black.


Instagram and Vine will soon be available on Lumia devices too, Nokia announced. App availability is still Windows Phone's Achilles heel, but the availability of those two third-party apps is a step in the right direction.


With these two large-screen smartphones, often called "phablets" due to being halfway in size between a smartphone and a tablet, Nokia is entering a competitive market, up against devices including the Samsung Galaxy Note 3 and the HTC One Max.


Nokia also hopes to better compete with low-end Android devices with three new Asha phones, including the Asha 503 with 3G for US$99.


Source: http://podcasts.infoworld.com/d/mobile-technology/nokia-debuts-its-first-windows-tablet-two-phablets-and-three-cheap-phones-229250?source=rss_mobile_technology
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‘Captain America: The Winter Soldier’ Teaser Trailer Video Starring Chris Evans, Scarlett Johansson

Watch the first teaser trailer for ‘Captain America: The Winter Soldier’ with Chris Evans as the title character, the iconic patriotic Marvel superhero and his alter ego Steve Rogers. Anticipation builds for the new movie which is the sequel to ‘Captain America: The First Avenger.’ The full teaser trailer video has been added below. It was kept under wraps, and for a day it was still under wraps. Marvel Entertainment gave us a teaser of the teaser trailer. It was the first glimpse of the movie, which was followed, a day later by full-length version which was added below as soon as it debuted. But for a full 24 hours, we had nothing but 10 seconds which, in retrospect, was better than zero so we can count ourselves lucky! The movie’s star, the 32-year-old Chris Evans has become a veteran of superhero movies, having portrayed Johnny Storm a.k.a. Human Torch in two of the ‘Fantastic Four’ movies, as well as Captain America in the original 2011 movie — which saw his transformation from the frail and ill Steve Rogers into the patriotic superhero. He also starred as Captain America in ‘The Avengers’ of 2012. The movie also stars Scarlett Johansson [...]Source: http://feedproxy.google.com/~r/RightCelebrity/~3/NcabURgvnGY/
Category: britney spears   Rashad Johnson   Theresa Vail   Justin Timberlake Vma   greg oden  

Portable vision screening devices accurately identify vision problems in young children

Portable vision screening devices accurately identify vision problems in young children


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25-Oct-2013



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Contact: Debbie Jacobson
djacobson@aap.org
847-434-7084
American Academy of Pediatrics



New guidelines and technical advances likely to increase amblyopia screening in pediatric practice



ORLANDO, Fla. Portable screening devices allow pediatricians to successfully screen children for vision problems, including amblyopia, according to an abstract presented Oct. 25 at the American Academy of Pediatrics (AAP) National Conference and Exhibition in Orlando.


Approximately 15 percent of children ages 3 to 5 have vision problems that can threaten normal visual development. In "Practical Validation of Plusoptix, iScreen, SPOT and iCheckKids* Photoscreeners in Young and Developmentally Delayed Pediatric Patients," researchers tested the effectiveness of four state-of-the-art portable vision screening devices in 108 pediatric patients in Alaska.


The children were ages 6 months to 10 years. Each received a comprehensive exam, followed by screening with each of the four vision screening devices, including the iCheckKids device which attaches to a smartphone.


All four devices performed well, according to the study authors. The devices' sensitivity/specificity ratings were comparable: iScreen had a 75 percent/88 percent sensitivity/specificity reading; SPOT, 80 percent/85 percent; Plusoptix, 83 percent/88 percent; and the iCheckKids, 81 percent/91 percent. The outcomes were similar for preschool-age children and developmentally delayed children.


"Photoscreening is exquisitely capable of detecting the most common, and the most treatable amblyopia risk factor, such as insufficiently accommodated hyperopia or farsightedness," said lead author Robert Arnold, MD. "A simple snap of your camera shutter will save a child's sight for life."


These new devices, combined with the AAP's updated vision screening guidelines and a reimbursement code (99174) for these services, "promise to improve early screening for amblyopia," Dr. Arnold said.


###

*ICheckKids will be called GoCheckKids in the future.


To view the abstract, "Practical Validation of Plusoptix, Iscreen, SPOT and ICheckKids Photoscreeners in Young and Developmentally Delayed Pediatric Patients,"
go to https://aap.confex.com/aap/2013/webprogrampress/Paper20691.html



Editor's Note: Several of these apps are the subject of other abstracts presented at the AAP meeting. These abstracts include: "Photoscreening for Refractive Error and Strabismus with a Smartphone App," and "The Need to Modernize Vision-Screening Practices in Schools." For information on contacting the authors, contact the AAP Department of Public Affairs.



The American Academy of Pediatrics is an organization of 60,000 primary care pediatricians, pediatric medical subspecialists and pediatric surgical specialists dedicated to the health, safety and well being of infants, children, adolescents and young adults. For more information, visit http://www.aap.org.




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Portable vision screening devices accurately identify vision problems in young children


[ Back to EurekAlert! ]

PUBLIC RELEASE DATE:

25-Oct-2013



[


| E-mail

]


Share Share

Contact: Debbie Jacobson
djacobson@aap.org
847-434-7084
American Academy of Pediatrics



New guidelines and technical advances likely to increase amblyopia screening in pediatric practice



ORLANDO, Fla. Portable screening devices allow pediatricians to successfully screen children for vision problems, including amblyopia, according to an abstract presented Oct. 25 at the American Academy of Pediatrics (AAP) National Conference and Exhibition in Orlando.


Approximately 15 percent of children ages 3 to 5 have vision problems that can threaten normal visual development. In "Practical Validation of Plusoptix, iScreen, SPOT and iCheckKids* Photoscreeners in Young and Developmentally Delayed Pediatric Patients," researchers tested the effectiveness of four state-of-the-art portable vision screening devices in 108 pediatric patients in Alaska.


The children were ages 6 months to 10 years. Each received a comprehensive exam, followed by screening with each of the four vision screening devices, including the iCheckKids device which attaches to a smartphone.


All four devices performed well, according to the study authors. The devices' sensitivity/specificity ratings were comparable: iScreen had a 75 percent/88 percent sensitivity/specificity reading; SPOT, 80 percent/85 percent; Plusoptix, 83 percent/88 percent; and the iCheckKids, 81 percent/91 percent. The outcomes were similar for preschool-age children and developmentally delayed children.


"Photoscreening is exquisitely capable of detecting the most common, and the most treatable amblyopia risk factor, such as insufficiently accommodated hyperopia or farsightedness," said lead author Robert Arnold, MD. "A simple snap of your camera shutter will save a child's sight for life."


These new devices, combined with the AAP's updated vision screening guidelines and a reimbursement code (99174) for these services, "promise to improve early screening for amblyopia," Dr. Arnold said.


###

*ICheckKids will be called GoCheckKids in the future.


To view the abstract, "Practical Validation of Plusoptix, Iscreen, SPOT and ICheckKids Photoscreeners in Young and Developmentally Delayed Pediatric Patients,"
go to https://aap.confex.com/aap/2013/webprogrampress/Paper20691.html



Editor's Note: Several of these apps are the subject of other abstracts presented at the AAP meeting. These abstracts include: "Photoscreening for Refractive Error and Strabismus with a Smartphone App," and "The Need to Modernize Vision-Screening Practices in Schools." For information on contacting the authors, contact the AAP Department of Public Affairs.



The American Academy of Pediatrics is an organization of 60,000 primary care pediatricians, pediatric medical subspecialists and pediatric surgical specialists dedicated to the health, safety and well being of infants, children, adolescents and young adults. For more information, visit http://www.aap.org.




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Source: http://www.eurekalert.org/pub_releases/2013-10/aaop-pvs101713.php
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Researchers identify gene variant that raises risk for colorectal cancer from eating processed meat

Researchers identify gene variant that raises risk for colorectal cancer from eating processed meat


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24-Oct-2013



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Contact: Suzanne Wu
suzanne.wu@usc.edu
213-740-0252
University of Southern California



Discovery sets first step towards identification of genetic variants linked to carcinogenic risk from diet and nutrition



A common genetic variant that affects 1 in 3 people significantly increases the risk of colorectal cancer from the consumption of red meat and processed meat, according to a study presented today at the annual American Society of Human Genetics 2013 meeting, the largest gathering of human geneticists in the world.


In addition to identifying a gene that raises risk for colorectal cancer from eating red or processed meat, the study the first to identify the interactions of genes and diet on a genome-wide scale also reveals another specific genetic variation that appears to modify whether eating more vegetables, fruits and fiber actually lowers your colorectal cancer risk.


"Diet is a modifiable risk factor for colorectal cancer. Our study is the first to understand whether some individuals are at higher or lower risk based on their genomic profile. This information can help us better understand the biology and maybe in the future lead to targeted prevention strategies," said lead author Jane Figueiredo, Ph.D., Assistant Professor of Preventive Medicine at the Keck School of Medicine of USC.


"But we are not saying that if you don't have the genetic variant that you should eat all the red meat you'd like," Figueiredo added. "People with the genetic variant allele have an even higher increased risk of colorectal cancer if they consume high levels of processed meat, but the baseline risk associated with meat is already pretty bad."


We've all heard reports about how certain foods may lower or raise the risk for certain diseases, such as cancer. But how our personal genetic variations modify the effects of diet on disease has not yet been thoroughly investigated, said senior author Ulrike Peters, Ph.D., M.P.H, of the Fred Hutchinson Cancer Research Center's Public Health Sciences Division.


The researchers systematically searched the more than 2.7 million genetic sequences for interactions with consumption of red and processed meat. The study looked at 9,287 patients with colorectal cancer and a control group of 9,117 individuals without cancer.


The risk of colorectal cancer associated with processed meat was significantly higher among people with the genetic variant rs4143094, the study shows. This variant is located on the same chromosome 10 region that includes GATA3, a transcription factor gene previously linked to several forms of cancer. The transcription factor encoded by this gene normally plays a role in the immune system, but carries this genetic variant in about 36 percent of the population.


The researchers speculate that the digestion of processed meat may promote an immunological or inflammatory response that may trigger tumor development. The GATA3 transcription factor normally would help suppress the immunological or inflammatory response. However, if the GATA3 gene region contains a genetic variant, it may encode a dysregulated transcription factor that impacts its ability to suppress the response.


But other genetic vatiants may be beneficial: On chromosome 8, another statistically significant diet-gene interaction was found in variant rs1269486. For people with this variant, eating your fruits and veggies may be even better for you when it comes to colorectal cancer risk, the research shows.


The study is part of an ongoing collaboration among multiple institutions worldwide, the international NIH-funded Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO).


"GECCO aims to continue to discover additional colorectal cancer-related variants by investigating how genetic variants are modified by other environmental and lifestyle risk factors, including biomarkers as well as how they influence patient treatment response and survival," Peters said, emphasizing how much further research is required to uncover the specific mechanisms by which genes modulate the intake of certain foods on colorectal cancer risk.


Colorectal cancer is a multi-factorial disease attributed to lifestyle, environmental and genetic causes, and the third leading cause of cancer death in both men and women across most racial groups. Over 30 genetic susceptibility alleles for colorectal cancer have been pinpointed throughout the genome. They include rare variants that have a strong impact on risk and common variants that are low risk.


"Colorectal cancer is a disease that is strongly influenced by certain types of diets," Figueiredo said. "We're showing the biological underpinnings of these correlations, and understand whether genetic variation may make some people more or less susceptible to certain carcinogens in food, which may have future important implications for prevention and population health."

###


Li Hsu, Ph.D., of the Fred Hutchinson Cancer Research Center was the study's lead biostatiscian.


To request a copy of the study, "Genome-wide analyses highlight gene interaction with processed meat and vegetable intake for colorectal cancer risk," contact Cathy Yarbrough at press@ashg.org. To request an interview with a researcher, contact Suzanne Wu at suzanne.wu@usc.edu.


About Keck Medicine of USC


Keck Medicine of USC is the University of Southern California's medical enterprise, one of only two university-owned academic medical centers in the Los Angeles area. Encompassing academic, research and clinical entities, it consists of the Keck School of Medicine of USC, one of the top medical schools in Southern California; the renowned USC Norris Comprehensive Cancer Center, one of the first comprehensive cancer centers established in the United States; the USC Care faculty practice; the Keck Medical Center of USC, which includes two acute care hospitals: 411-bed Keck Hospital of USC and 60-bed USC Norris Cancer Hospital; and USC Verdugo Hills Hospital, a 158-bed community hospital. It also includes outpatient facilities in Beverly Hills, downtown Los Angeles, La Caada Flintridge, Pasadena, and the USC University Park campus. USC faculty physicians and Keck School of Medicine departments also have practices throughout Los Angeles, Orange and Riverside counties.


About ASHG


The American Society of Human Genetics is the primary professional membership organization for nearly 8,000 human genetics specialists worldwide. The ASHG Annual Meeting is the world's largest gathering of human genetics professionals and a forum for renowned experts in the field. For more information about ASHG, visit: http://www.ashg.org.




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Researchers identify gene variant that raises risk for colorectal cancer from eating processed meat


[ Back to EurekAlert! ]

PUBLIC RELEASE DATE:

24-Oct-2013



[


| E-mail

]


Share Share

Contact: Suzanne Wu
suzanne.wu@usc.edu
213-740-0252
University of Southern California



Discovery sets first step towards identification of genetic variants linked to carcinogenic risk from diet and nutrition



A common genetic variant that affects 1 in 3 people significantly increases the risk of colorectal cancer from the consumption of red meat and processed meat, according to a study presented today at the annual American Society of Human Genetics 2013 meeting, the largest gathering of human geneticists in the world.


In addition to identifying a gene that raises risk for colorectal cancer from eating red or processed meat, the study the first to identify the interactions of genes and diet on a genome-wide scale also reveals another specific genetic variation that appears to modify whether eating more vegetables, fruits and fiber actually lowers your colorectal cancer risk.


"Diet is a modifiable risk factor for colorectal cancer. Our study is the first to understand whether some individuals are at higher or lower risk based on their genomic profile. This information can help us better understand the biology and maybe in the future lead to targeted prevention strategies," said lead author Jane Figueiredo, Ph.D., Assistant Professor of Preventive Medicine at the Keck School of Medicine of USC.


"But we are not saying that if you don't have the genetic variant that you should eat all the red meat you'd like," Figueiredo added. "People with the genetic variant allele have an even higher increased risk of colorectal cancer if they consume high levels of processed meat, but the baseline risk associated with meat is already pretty bad."


We've all heard reports about how certain foods may lower or raise the risk for certain diseases, such as cancer. But how our personal genetic variations modify the effects of diet on disease has not yet been thoroughly investigated, said senior author Ulrike Peters, Ph.D., M.P.H, of the Fred Hutchinson Cancer Research Center's Public Health Sciences Division.


The researchers systematically searched the more than 2.7 million genetic sequences for interactions with consumption of red and processed meat. The study looked at 9,287 patients with colorectal cancer and a control group of 9,117 individuals without cancer.


The risk of colorectal cancer associated with processed meat was significantly higher among people with the genetic variant rs4143094, the study shows. This variant is located on the same chromosome 10 region that includes GATA3, a transcription factor gene previously linked to several forms of cancer. The transcription factor encoded by this gene normally plays a role in the immune system, but carries this genetic variant in about 36 percent of the population.


The researchers speculate that the digestion of processed meat may promote an immunological or inflammatory response that may trigger tumor development. The GATA3 transcription factor normally would help suppress the immunological or inflammatory response. However, if the GATA3 gene region contains a genetic variant, it may encode a dysregulated transcription factor that impacts its ability to suppress the response.


But other genetic vatiants may be beneficial: On chromosome 8, another statistically significant diet-gene interaction was found in variant rs1269486. For people with this variant, eating your fruits and veggies may be even better for you when it comes to colorectal cancer risk, the research shows.


The study is part of an ongoing collaboration among multiple institutions worldwide, the international NIH-funded Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO).


"GECCO aims to continue to discover additional colorectal cancer-related variants by investigating how genetic variants are modified by other environmental and lifestyle risk factors, including biomarkers as well as how they influence patient treatment response and survival," Peters said, emphasizing how much further research is required to uncover the specific mechanisms by which genes modulate the intake of certain foods on colorectal cancer risk.


Colorectal cancer is a multi-factorial disease attributed to lifestyle, environmental and genetic causes, and the third leading cause of cancer death in both men and women across most racial groups. Over 30 genetic susceptibility alleles for colorectal cancer have been pinpointed throughout the genome. They include rare variants that have a strong impact on risk and common variants that are low risk.


"Colorectal cancer is a disease that is strongly influenced by certain types of diets," Figueiredo said. "We're showing the biological underpinnings of these correlations, and understand whether genetic variation may make some people more or less susceptible to certain carcinogens in food, which may have future important implications for prevention and population health."

###


Li Hsu, Ph.D., of the Fred Hutchinson Cancer Research Center was the study's lead biostatiscian.


To request a copy of the study, "Genome-wide analyses highlight gene interaction with processed meat and vegetable intake for colorectal cancer risk," contact Cathy Yarbrough at press@ashg.org. To request an interview with a researcher, contact Suzanne Wu at suzanne.wu@usc.edu.


About Keck Medicine of USC


Keck Medicine of USC is the University of Southern California's medical enterprise, one of only two university-owned academic medical centers in the Los Angeles area. Encompassing academic, research and clinical entities, it consists of the Keck School of Medicine of USC, one of the top medical schools in Southern California; the renowned USC Norris Comprehensive Cancer Center, one of the first comprehensive cancer centers established in the United States; the USC Care faculty practice; the Keck Medical Center of USC, which includes two acute care hospitals: 411-bed Keck Hospital of USC and 60-bed USC Norris Cancer Hospital; and USC Verdugo Hills Hospital, a 158-bed community hospital. It also includes outpatient facilities in Beverly Hills, downtown Los Angeles, La Caada Flintridge, Pasadena, and the USC University Park campus. USC faculty physicians and Keck School of Medicine departments also have practices throughout Los Angeles, Orange and Riverside counties.


About ASHG


The American Society of Human Genetics is the primary professional membership organization for nearly 8,000 human genetics specialists worldwide. The ASHG Annual Meeting is the world's largest gathering of human genetics professionals and a forum for renowned experts in the field. For more information about ASHG, visit: http://www.ashg.org.




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Source: http://www.eurekalert.org/pub_releases/2013-10/uosc-102213.php
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